张成

作者:生命科学院 | 来源: | 发布日期:2014-03-06 | 阅读次数:


 

姓     名:张  成
职     称:副教授
研究方向:生殖调控与信号传导
电     话:+86-10-68903623
邮     箱:chzhang2011@cnu.edu.cn
 


教育背景:
1999—2003  宁夏大学         获学士学位
2003—2006  宁夏大学         获硕士学位
2007—2011  中国农业大学     获博士学位
工作经历:
2006—2007   宁夏四正生物工程技术研究中心   技术 员
(牛、羊胚胎移植、冷冻精液研发和生产)
2008—2011   University of Ottawa(OHRI)   访问学者
2011—2013   首都师范大学生命科学学院       讲    师
2014—       首都师范大学生命科学学院       副 教 授
2016—       北京市教育委员会                        挂职锻炼

获奖情况:
2008-2010    获得国家留学基金委(CSC)奖学金
2010         获得加拿大REDIH 奖学金
2012-2015    首都师范大学工会积极分子
2014         首都师范大学青年标兵
2014         首都师范大学青年教师教学基本功竞赛二等奖
2014         首都师范大学青年教师教学基本功竞赛最佳教案奖
2014         荣获第47届国际生殖研究学会(The Society for the Study of Reproduction , SSR, USA) “国际最佳摘要奖”[Effects of Gonadotropin on Fas/FasL Expression and Proliferation in Rat Ovary]
2015          首都师范大学优秀班主任
 
主要研究领域:
主要从事卵巢细胞增殖、分化的内分泌、旁分泌和自分泌调节和细胞信号传导机制的研究。所从事的科研项目不仅完善了大鼠/小鼠卵泡体外培养模型,而且通过该体系以及颗粒细胞体外培养体系进一步研究了甲状腺素调节卵泡发育的相关机理。另外,本实验室也在探索卵巢癌及多囊卵巢综合症(Polycysticovariansyndrome, PCOS) 发病机理的相关研究。通过这些工作可使我们对于卵巢癌和多囊卵巢综合症等病理情况有更多认识,以期解决当今人类生殖健康难题,为生殖辅助技术提供坚实的理论基础,从而为人类健康做出应有的贡献。
 
科研项目:
1. 甲状腺素调节卵巢卵泡发育机理的研究 [博士启动基金,主持]  
2. 家禽产业技术体系——蛋鸡营养与饲料[北京市创新团队[主持—横向]
3. 甲状腺素调控大鼠卵巢细胞葡萄糖吸收机制的研究[北京市留学回国人员择优资助项目,主持]
4. 甲状腺素对大鼠卵泡细胞增殖、凋亡及PCOS卵巢作用机制的研究[北京市优秀人才培养资助项目,主持]
5. 甲状腺素/促性腺激素调节小鼠腔前卵泡发育机制的研究[北京市自然科学基金面上项目,5142003,主持)]
6. 甲状腺素/促性腺激素调节大鼠卵巢葡萄糖吸收机制的研究[国家自然科学基金青年科学基金项目,31300958,主持]
7. T3/FSH调节大鼠卵巢Glut1-4表达机制的研究[北京市教育委员会科技计划项目,KM2016100280,主持]
8. NO介导甲状腺素调节大鼠卵泡发育机制的研究[国家自然科学基金面上项目,31671555,主持]
 
发表论文及摘要:

1. Ding Yu, Tian Ye, Guo Meng, Juan Liu, Dai Heng, Baochang, Yanzhou Yang, Cheng Zhang. Regulation of glucose transport by thyroid hormone in rat ovary. Cell and Tissue Research, 2016 Jul 14. DOI: 10.1007/s00441-016-2453-3

2. Yanzhou Yang, Hoi Hung Cheung, Wai Nok Law, Cheng Zhang, Wai Yee Chan, Xiuying Pei, Yanrong Wang. New insights into the role of autophagy in ovarian cryopreservation by vitrification. Biology of Reproduction, 2016 Jun;94(6):137.

3. Yanzhou Yang, Xiuying Pei, Yaping Jin, Yanrong Wang, Cheng Zhang. The roles of endoplasmic reticulum stress response in female mammalian reproduction. Cell and Tissue Research, 2016 Mar: 363(3):589-97.

4. Yun Feng, Yu Ding, Juan Liu, Ye Tian, Shuluan Guan, Yanzhou Yang, Cheng Zhang. Effects of dietary omega-3/omega-6 fatty acid ratios on reproduction in the young breeder rooster. BMC Veterinary Research, 2015 Mar 21; 11: 73.

5. Shuluan Guan , Li Guo, Tao Zhang, Baochang Zhu, Xiaoxia Wang, Cheng Zhang. Effects of gonadotropin on Fas and/or FasL expression and proliferation in rat ovary. Theriogenology, 2015 Jan 1; 83 (1):21-9.

6. Cheng Zhang, Xiaoxia Wang, Wang Zhengpin, Niu Wanbao, Zhu Baochang, Xia Guoliang. Effect of different culture systems and 3, 5, 3'-triiodothyronine/follicle-stimulating hormone on preantral follicle development in mice. PloS One, 2013 15;8(4):e61947.

7. Cheng Zhang, Li Guo, Baochang Zhu, Yun Feng, Shangyu Yu, Na An, Xiaoxia Wang. Effects of 3, 5, 3'-Triiodothyronine (T3) and follicle stimulating hormone on apoptosis and proliferation of rat ovarian granulosa cells.Chinese Journal of Physiology, 2013 Oct 31;56(5).  

8. Cheng Zhang, Wanbo Niu, Zhengpin Wang, Xiaoxia Wang, Guoliang Xia. The effect of gonadotropin on glucose transport and apoptosis in rat ovary. PloS One, 2012;7(8):e42406.

9. Cheng Zhang, Guoliang Xia, Benjamin K. Tsang. Interactions of thyroid hormone and FSH   in the regulation of rat granulosa cell apoptosis. Frontiers in Bioscience, 2011 Jun 1;3:1401-1413. 

10. Cheng Zhang, Guoliang Xia, Benjamin K. Tsang. Actions and Interactions of Thyroid Hormone and Follicle-Stimulating Hormone in the Regulation of Rat Granulosa Cell Apoptosis. Biology of Reproduction, 2010, 83: 597.

11. Chao Wang, Baoshan Xu, Bo Zhou, Cheng Zhang, Jie Yang, Hong Ouyang, Gang Ning,   Meijia Zhang, Jianzhong Shen, and Guoliang Xia. Reducing CYP51 inhibits follicle-stimulating hormone induced resumption of mouse oocyte meiosis in vitro.     Journal of Lipid Research, 2009, 50: 2164 - 2172.

12. Baoshan Xu, Chao Wang, Jie Yang, Guanping Mao, Cheng Zhang, Dan Liu, Ping Tai, Bo Zhou, Guoliang Xia, and Meijia Zhang. Silencing of mouse hepatic lanosterol 14-alpha  demethylase down-regulated plasma low-density lipoprotein cholesterol levels by short-term  treatment of siRNA . Biological & Pharmaceutical Bulletin, 2008, 31:1182-91   

13. Cheng Zhang, Shuluan Guan. Effects of Gonadotropin on Fas/FasL Expression and Proliferation in Rat Ovary. The Society for the Study of Reproduction (SSR), 2014.07. (Michigan ,USA)

14. Cheng Zhang, Guoliang Xia, Benjamin K. Tsang. Role of Thyroid Hormone and Follicle-Stimulating Hormone on the Regulation of Rat Granulosa Cell Apoptosis In Vitro. Ottawa Reproduction Workshop, 2010, 04. (Ottawa, Canada)

15.  Cheng Zhang, Patrik Vahlberg, Guoliang Xia, Benjamin K. Tsang. Regulation of Ovarian Follicular Growth and Atresia by Thyroid Hormone. 9th Annual OHRI RESEARCH DAY, 2009, 11. (Ottawa, Canada)

参编:《动物生理学》(华中科技大学出版社,全国普通高校“十二五”规划教材)及《细胞生物学实验》(科学出版社)