张玮玮

作者: | 来源: | 发布日期:2012-09-20 | 阅读次数:

 

  张玮玮,博士

  电话: 010-68901494

  E-mail: zhangww@cnu.edu.cn

 

研究领域

细胞分化贯穿人类胚胎发育和生命活动的始终。异常的细胞分化会导致严重的病理性后果,例如:发育异常性疾病、恶性肿瘤等。因此,深入理解调控细胞分化的分子机制对这些疾病的有效预防和治疗至关重要。我们的研究主要以具有分化能力的胚胎干细胞和低分化肿瘤为对象,从转录调控、翻译后修饰等角度,针对以下三方面进行深入探索:

1、维持胚胎干细胞自我更新和多能性的分子机制

2、胚胎干细胞向各胚层细胞谱系进行定向分化的调控机制

3、低分化恶性肿瘤的发病机制 

 

教育背景

20042008年     新加坡国立大学    生物学博士

19972002年     北京大学医学部    医学学士

 

科研及工作经历

2009年至今        首都师范大学生命科学院    副教授

20082009年    首都师范大学生命科学院    讲师

2008年            新加坡国立大学生物系      助理研究员

 

 

发表文章(注:* 通讯作者)

(1) Zhaoyan Li, Yan Wang, Yadan Li, Wanqi Yin, Libin Mo, Xianghao Qian, Yiran Zhang, Guifen Wang, Fan Bu, Zhiling Zhang, Xiaofang Ren, Baochang Zhu, Chang Niu, Wei Xiao*, Weiwei Zhang*. Ube2s stabilizes β-Catenin through K11-linked polyubiquitination to promote mesendoderm specification and colorectal cancer development, Cell Death and Disease, 2018, 9, 456.

 

(2) Weiwei Zhang, Yuan Zhuang, Yiran Zhang, Xiaoran Yang, Hong Zhang, Guifen Wang, Wanqi Yin, Ruifeng Wan,Zhiling Zhang,Wei Xiao. Uev1A facilitates osteosarcoma differentiation by promoting Smurf1-mediated Smad1 ubiquitination and degradation. Cell Death and Disease20178e2974.

 

(3) Juanjuan WangYiran ZhangJie HouXianghao QianHong ZhangZhiling ZhangMengya LiRuifeng WangKunpeng LiaoYan WangZhaoyan LiDan ZhongPing WanLin DongFengyu LiuXiaomin WangYou WanWei Xiao*Weiwei Zhang*Ube2s regulates Sox2 stability and mouse ES cell maintenance.Cell Death and Differentiation2016233):393-404.

 

(4) Zhaojia WuSiqi ShenZhiling ZhangWeiwei ZhangWei Xiao*Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-kappa B mediated matrix metalloproteinase-1 gene regulationBreast Cancer Research2014164):R75.

 

(5) Lei LiJuanjuan WangJie HouZhaojia WuYuan ZhuangMengxue

LuYiran ZhangXiaohan ZhouZhaoyan LiWei Xiao*Weiwei Zhang*Cdk1 interplays with Oct4 to repress differentiation of embryonic stem cells into trophectodermFEBS Letters201258623):4100-4107.

 

(6) 王娟娟,刘会贤,侯杰,张玮玮*,Cdk6在维持ES细胞自我更新中的作用,中国生物化学与分子生物学报,2012,28:958-965.

 

(7) Weiwei Zhang*Xiaojie ZhangHuixian LiuJie ChenYonghong RenDenggao HuangXianghong ZouWei XiaoCdk1 Is Required for the Self-Renewal of Mouse Embryonic Stem CellsJournal of Cellular Biochemistry20111123):942-948.

—作为封面文章

 

(8) Weiwei ZhangZhoushuai QinXiaojie ZhangWei XiaoRoles of sequential ubiquitination of PCNA in DNA-damage toleranceFEBS Letters201158518):2786-2794.

 

(9) Yuinhan Loh#Weiwei Zhang#Xi ChenJoshy GeorgeHuckhui NgJmjd 1a and Jmjd2c histone H3 lysine 9 demethylases regulate self-renewal in embryonic stem cellsGenes & Development20072120):2545-2557.

# 并列第一作者

 

(10) Yongsheng WuXiaoling FengYucui JinZhaojia WuWilliam HankeyCarolyn PaisieLei LiFengjuan LiuSanford H. BarskyWeiwei ZhangRamesh GanjuXianghong ZouA Novel Mechanism of Indole-3-Carbinol Effects on Breast Carcinogenesis Involves Induction of Cdc25A DegradationCancer Prevention Research201037):818-828.

 

(11) 刘会贤,张玮玮*,维持胚胎干细胞生物学特性的分子调控机制,中国生物化学与分子生物学报,2010,12:1073-1079.

 

(12) Bo Feng Jianming JiangPetra KrausJia-Hui NgJian-Chien Dominic HengYun-Shen ChanLai-Ping YawWeiwei ZhangYuin-Han LohJianyong HanVinsensius B VegaValere Cacheux-RataboulBing LimThomas LufkinHuck-Hui NgReprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor EsrrbNature Cell Biology2009112):197-203.

 

(13) Xi ChenHan XuPing YuanFang FangMikael HussVinsensius B VegaEleanor WongYuriy L OrlovWeiwei ZhangJianming JiangYuin-Han LohHock Chuan YeoZhen Xuan YeoVipin NarangKunde Ramamoorthy GovindarajanBernard LeongAtif ShahabYijun RuanGuillaume BourqueWing-Kin SungNeil D ClarkeChia-Lin WeiHuck-Hui NgIntegration of external signaling pathways with the core transcriptional network in embryonic stem cellsCell20081336):1106-1117.

 

(14) Linda Shushan LimYuinhan LohWeiwei ZhangYixun LiXi ChenYinan WangManjiri BakreHuckhui NgLawrence W. StantonZic3 is required for maintenance of pluripotency in embryonic stem cellsMolecular Biology of the Cell2007184):1348-1358.

 

(15) Yuinhan LohQiang WuJoonlin ChewVinsensius B VegaWeiwei ZhangXi ChenGuillaume BourqueJoshy GeorgeBernard LeongJun LiuKeeyew WongKen W SungCharlie W H LeeXiaodong ZhaoKuoping ChiuLeonard LipovichVladimir A KuznetsovPaul RobsonLawrence W StantonChia-Lin WeiYijun RuanBing LimHuckhui NgThe Oct4 and Nanog transcription network regulates pluripotency in mouse embryonicstem cellsNature Genetics2006384):431-440.

 

 

主要荣誉及奖励

2018年        首都师范大学优秀共产党员     

2018年        首都师范大学第九届“最受学生欢迎的十佳教师”

2015年        第五届首都师范大学青年教师优秀教学奖

2015年        首都师范大学“青年标兵”

2015年        首都师范大学优秀主讲教师

2014年        2012-2014学年首都师范大学教育实习优秀指导教师

2010年        首都师范大学本科生科研“优秀指导教师”称号

2010年        首都师范大学青年教师教学基本功大赛一等奖