张玮玮

作者: | 来源: | 发布日期:2012-09-20 | 阅读次数:

 

  张玮玮,博士

  电话: 010-68901494

  E-mail: zhangww@cnu.edu.cn

 

 研究领域

    细胞分化贯穿人类胚胎发育和生命活动的始终。异常的细胞分化会导致严重的病理性后果,例如:发育异常性疾病、恶性肿瘤等。因此,深入理解调控细胞分化的分子机制对这些疾病的有效预防和治疗至关重要。我们的研究主要以具有分化能力的胚胎干细胞和低分化肿瘤为对象,从转录调控、翻译后修饰等角度,针对以下三方面进行深入探索:

1、维持胚胎干细胞自我更新和多能性的分子机制

2、胚胎干细胞向各胚层细胞谱系进行定向分化的调控机制

3、低分化恶性肿瘤的发病机制

硕士招生专业:071010生物化学与分子生物学--08干细胞生物学与细胞分化

教育背景

2004年2008年     新加坡国立大学        生物学博士

1997年2002年     北京大学医学部        医学学士

 

科研及工作经历

2009年至今         首都师范大学生命科学院   副教授

2008年2009年     首都师范大学生命科学院   讲师

2008年             新加坡国立大学生物系    助理研究员

 

发表文章

(1) Weiwei Zhang, Yuan Zhuang, Yiran Zhang, Xiaoran Yang, Hong Zhang, Guifen Wang, Wanqi Yin, Ruifeng Wan,Zhiling Zhang,Wei Xiao. Uev1A facilitates osteosarcoma differentiation by promoting Smurf1-mediated Smad1 ubiquitination and degradation. Cell Death and Disease20178e2974.

 

(2) Juanjuan WangYiran ZhangJie HouXianghao QianHong ZhangZhiling ZhangMengya LiRuifeng WangKunpeng LiaoYan WangZhaoyan LiDan ZhongPing WanLin DongFengyu LiuXiaomin WangYou WanWei Xiao*Weiwei Zhang*Ube2s regulates Sox2 stability and mouse ES cell maintenance.Cell Death and Differentiation2016233):393-404.

* 通讯作者

 

(3) Zhaojia WuSiqi ShenZhiling ZhangWeiwei ZhangWei Xiao*Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-kappa B mediated matrix metalloproteinase-1 gene regulationBreast Cancer Research2014164):R75.

* 通讯作者

 

(4) Lei LiJuanjuan WangJie HouZhaojia WuYuan ZhuangMengxue

LuYiran ZhangXiaohan ZhouZhaoyan LiWei Xiao*Weiwei Zhang*Cdk1 interplays with Oct4 to repress differentiation of embryonic stem cells into trophectodermFEBS Letters201258623):4100-4107.

* 通讯作者

 

(5) 王娟娟,刘会贤,侯杰,张玮玮*,Cdk6在维持ES细胞自我更新中的作用,中国生物化学与分子生物学报,2012,28:958-965.

* 通讯作者

 

(6) Weiwei Zhang*Xiaojie ZhangHuixian LiuJie ChenYonghong

RenDenggao HuangXianghong ZouWei XiaoCdk1 Is Required for the

Self-Renewal of Mouse Embryonic Stem CellsJournal of Cellular Biochemistry20111123):942-948.

* 通讯作者

—作为封面文章

 

(7) Weiwei ZhangZhoushuai QinXiaojie ZhangWei XiaoRoles of sequential ubiquitination of PCNA in DNA-damage toleranceFEBS Letters201158518):2786-2794.

 

(8) Yuinhan Loh#Weiwei Zhang#Xi ChenJoshy GeorgeHuckhui NgJmjd 1a and Jmjd2c histone H3 lysine 9 demethylases regulate self-renewal in embryonic stem cellsGenes & Development20072120):2545-2557.

# 并列第一作者

 

(9) Yongsheng WuXiaoling FengYucui JinZhaojia WuWilliam HankeyCarolyn PaisieLei LiFengjuan LiuSanford H. BarskyWeiwei ZhangRamesh GanjuXianghong ZouA Novel Mechanism of Indole-3-Carbinol Effects on Breast Carcinogenesis Involves Induction of Cdc25A DegradationCancer Prevention Research201037):818-828.

 

(10) 刘会贤,张玮玮*,维持胚胎干细胞生物学特性的分子调控机制,中国生物化学与分子生物学报,2010,12:1073-1079.

* 通讯作者

 

(11) Bo Feng Jianming JiangPetra KrausJia-Hui NgJian-Chien Dominic HengYun-Shen ChanLai-Ping YawWeiwei ZhangYuin-Han LohJianyong HanVinsensius B VegaValere Cacheux-RataboulBing LimThomas LufkinHuck-Hui NgReprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor EsrrbNature Cell Biology2009112):197-203.

 

(12) Xi ChenHan XuPing YuanFang FangMikael HussVinsensius B VegaEleanor WongYuriy L OrlovWeiwei ZhangJianming JiangYuin-Han LohHock Chuan YeoZhen Xuan YeoVipin NarangKunde Ramamoorthy GovindarajanBernard LeongAtif ShahabYijun RuanGuillaume BourqueWing-Kin SungNeil D ClarkeChia-Lin WeiHuck-Hui NgIntegration of external signaling pathways with the core transcriptional network in embryonic stem cellsCell20081336):1106-1117.

 

(13) Linda Shushan LimYuinhan LohWeiwei ZhangYixun LiXi ChenYinan WangManjiri BakreHuckhui NgLawrence W. StantonZic3 is required for maintenance of pluripotency in embryonic stem cellsMolecular Biology of the Cell2007184):1348-1358.

 

(14) Yuinhan LohQiang WuJoonlin ChewVinsensius B VegaWeiwei ZhangXi ChenGuillaume BourqueJoshy GeorgeBernard LeongJun LiuKeeyew WongKen W SungCharlie W H LeeXiaodong ZhaoKuoping ChiuLeonard LipovichVladimir A KuznetsovPaul RobsonLawrence W StantonChia-Lin WeiYijun RuanBing LimHuckhui NgThe Oct4 and Nanog transcription network regulates pluripotency in mouse embryonicstem cellsNature Genetics2006384):431-440.

 

 

主要荣誉及奖励

第五届首都师范大学青年教师优秀教学奖             2015

首都师范大学“青年标兵”                         2015

首都师范大学优秀主讲教师                         2015

2012-2014学年首都师范大学教育实习优秀指导教师    2014

首都师范大学本科生科研“优秀指导教师”称号       2010

首都师范大学青年教师教学基本功大赛一等奖         2010