施慧

作者: | 来源: | 发布日期:2017-06-30 | 阅读次数:

 

施慧,博士,研究员,博士生导师,

 

课题组组长,北京市长城学者

 

联系方式:

hui.shi@cnu.edu.cn

 

教育经历

2009-2014  生命科学学院,北京大学,博士

2012-2014  发育、细胞和分子生物学系,耶鲁大学,联合培养博士生

2010-2012  植物和微生物学系,加州大学伯克利分校,联合培养博士生

2005-2009  生命科学学院,北京大学,学士


工作经历

2016至今  生命科学学院,首都师范大学,研究员

2014-2016  生命科学学院,北京大学,博士后

 

研究方向

    课题组致力于研究植物种子萌发和幼苗形态发育的分子机制,综合运用分子遗传学、生物化学、基因组学等技术手段,重点关注外界环境因子和内源激素对种子萌发、幼苗暗形态建成和光形态建成的调控作用。

硕士招生方向

    071001植物学——植物种子萌发和形态建成

 

近五年发表主要论文:

    近五年来,施慧博士以通讯作者或第一作者在专业一流学术刊物PNAS、Developmental Cell (封面文章)、Current BiologyPlant Cell上发表了一系列高水平原创研究论文,并以合作作者发表原创论文多篇,在国际研究领域产生重要影响。研究成果被美国科学院院士Winslow R. Briggs等多位国际著名植物学家在Current Biology、Nature Plants、Trends in Plant Science、Developmental Cell以及Annual Review of Plant Biology上撰文评述和亮点推荐,并多次受到F1000的重点推荐。

 

评审任职:

2017年至今 国家自然科学基金函评专家

 

执教课程:

植物与环境,本科生一年级,秋季学期,通识拓展课

 

代表论文(近五年):

1.  Luo, Y. and Shi, H.* Direct Regulation of Phytohormone Actions by Photoreceptors. Trends in Plant Science, 2019, 24(2), 105-108.

2.  Shi, H., Lyu, M., Luo, Y., Liu, S., Li, Y., He, H., Wei, N., Deng, X.W.*, Zhong, S.* Genome-wide regulation of light-controlled seedling morphogenesis by three families of transcription factors. PNAS, 2018, 115(25):6482-6487.

3.  Pan, Y. and Shi, H.* Stabilizing the Transcription Factors by E3 Ligase COP1. Trends in Plant Science, 2017, 22, 999-1001.

4.  Liu, X., Liu, R., Li, Y., Shen, X., Zhong, S.*, and Shi, H.* EIN3 and PIF3 Form an Interdependent Module that Represses Chloroplast Development in Buried Seedlings. Plant Cell, 2017, 29(12), 3051-3067. (当期亮点文章,在当期刊物配发专家评述,当选为发表当月最受关注的TOP5文章,被F1000推荐)

5.  Shi, H., Shen, X., Liu, R., Xue, C., Wei, N., Deng, X.W.*, and Zhong, S.*(2016). The red light receptor phytochrome B directly enhances substrate-E3 ligaseinteractions to attenuate ethylene responses. Developmental Cell, 2016, 39(5), 597-610.(当期封面论文,在同期刊物上作为亮点论文评述推荐,被Science系列期刊Science Signaling选为Editor’s Choice论文做特别介绍,入选“2016中国科学家与Cell Press”特刊)

6.  Shi, H., Liu, R., Xue, C., Shen, X., Wei, N., Deng, X.W.*, and Zhong, S.* Seedlings Transduce the Depth and Mechanical Pressure of Covering Soil Using COP1 and Ethylene to Regulate EBF1/EBF2 for Soil Emergence. Current Biology, 2016, 26, 139-149.(在同期刊物上作为亮点论文评述推荐,被Nature系列期刊Nature Plant和植物学顶级综述期刊Trends in Plant Science做特别评述,入选“2016中国科学家与Cell Press”特刊)

7.  Shi, H., Wang, X., Mo, X., Tang, C., Zhong, S.*, and Deng, X.W.* Arabidopsis DET1 degrades HFR1 but stabilizes PIF1 to precisely regulate seed germination. PNAS, 2015, 112, 3817-3822.

8.  Shi, H., Zhong, S.W., Mo, X.R., Liu, N., Nezames, C.D., and Deng, X.W.* HFR1 Sequesters PIF1 to Govern the Transcriptional Network Underlying Light-Initiated Seed Germination in Arabidopsis. Plant Cell, 2013, 25, 3770-3784.

合作论文(近五年):

1.  Yu, Y., Wang, J., Shi, H., Gu, J., Dong, J., Deng, X.W. and Huang, R.* Salt stress and ethylene antagonistically regulate nucleocytoplasmic partitioning of COP1 to control seed germination. Plant Physiology, 2016, 170, 2340-50.

2.  Zhong, S.W., Shi, H., Xue, C., Wei, N., Guo, H.W., and Deng, X.W.* (2014). Ethylene-orchestrated circuitry coordinates a seedling's response to soil cover and etiolated growth. PNAS, 2014, 111, 3913-3920.

3.  Peng, J.Y., Li, Z.H., Wen, X., Li, W.Y., Shi, H., Yang, L.S., Zhu, H.Q., and Guo, H.W.* Salt-Induced Stabilization of EIN3/EIL1 Confers Salinity Tolerance by Deterring ROS Accumulation in Arabidopsis. Plos Genetics, 2014, 10.

4.  Pfeiffer, A., Shi, H., Tepperman, J.M., Zhang, Y., and Quail, P.H.* Combinatorial Complexity in a Transcriptionally Centered Signaling Hub in Arabidopsis. Molecular Plant, 2014, 7, 1598-1618.

5.  Zhang, Y., Mayba, O., Pfeiffer, A., Shi, H., Tepperman, J.M., Speed, T.P., and Quail, P.H.* A  quartet of PIF bHLH Factors Provides a Transcriptionally Centered Signaling Hub That Regulates  seedling Morphogenesis through Differential Expression-Patterning of Shared Target Genes in Arabidopsis. Plos Genetics, 2013, 9.