李周华

作者:生命科学院 | 来源: | 发布日期:2014-03-12 | 阅读次数:

 

  李周华/Zhouhua Li
  博士,教授/Ph.D., Professor
  Email: zhli@cnu.edu.cn

 

 

 

 
教育经历/Education:
2002/12—2009/04,新加坡国立大学淡马锡生命研究所,博士/Temasek
Life Sciences Laboratory, National University of Singapore (NUS),Ph.D.
1999/09—2002/07,中国农业大学生物学院,硕士/College of Biological Sciences,
China Agricultural University, Master
1995/09—1999/07,山东农业大学园艺学院,学士/College of Horticulture Sciences,
Shandong Agricultural University, Bachelor
 
研究工作经历/Professional Experience:
2013/11—至今/present,首都师范大学生命科学学院,教授/School of Life Sciences,
Capital Normal University, Professor
2010/09—2013/11,中国科学院动物研究所,副研究员/Institute of Zoology, Chinese
Academy of Sciences, Associate Professor
2010/05—2010/09,哈佛大学医学院,博士后/Harvard Medical School, Harvard
University,Post-Doc Fellow
2009/01—2010/04,新加坡国立大学淡马锡生命研究所,研究员/Temasek Life Sciences
Laboratory, NUS,Research Fellow
 
科研方向/Research Interests:
干细胞分为胚胎干细胞和成体干细胞。成体干细胞的自我维持和分化在维持成体组织稳态和组织再生中发挥着至关重要的作用。干细胞自我维持和分化失调会导致衰老和癌症等一系列重大疾病的发生(图1),但调控干细胞自我维持和分化的分子机理尚不明了,因此阐明干细胞自我维持和分化的分子机制对干细胞生物学研究和疾病治疗等领域具有重要的科学意义和应用价值。
本研究组以经典模式生物黑腹果蝇为研究对象,深入研究成体干细胞(生殖干细胞和肠道干细胞)自我维持和分化及组织稳态的调控机制(图2)。
  
   Figure 1. The balance of self-renewal and differentiation of stem cell is critical for tissue homeostasis. 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Figure 2. Different adult stem sell types studied in the lab.
GSC: germline stem cell; ISC: intestinal stem cell.
 
The most prominent properties of stem cell are self-renewal and differentiation.The balance of stem cell self-renewal and differentiation must be tightly regulated in order to maintain tissue/organism homeostasis. De-regulation of this process will lead to a variety of diseases, like cancer and degeneration (Fig. 1). However, the detailed mechanism controlling stem cell self-renewal and differentiation is not fully understood. Therefore, elucidating the molecular mechanism of stem cell regulation will provide new insights into our understanding of the mechanisms of stem cell proliferation and tissue homeostasis control, as well as the development of therapeutic applications to target human diseases.
  We are using Drosophila as a model system to study the mechanisms controlling stem cell self-renewal, proliferation, differentiation and tissue homeostasis. We mainly focus on adult stem cells, like female/male germline stem cell (GSC) and intestinal stem cell (ISC)(Fig.2).
 
发表论文(部分)/Selected Publications (*Corresponding author):
1.  Zhouhua Li*, Yueqin Guo, Lili Han, Yan Zhang, Lai Shi, Xudong Huang and Xinhua Lin*. 2014. Debra-mediated Ci degradation controls tissue homeostasis in Drosophila adult midgut. Stem Cell Reports, 2,135-144.
2.  Zhouhua Li, Yan Zhang, Lili Han, Lai Shi, Xinhua Lin*. 2013. Trachea-derived Dpp controls adult midgut homeostasis in Drosophila. Developmental Cell,24, 133-143.
3.  Zhouhua Li, Liwei Wang, Yu Cai*. 2008. Dynein-mediated apical localization of crumbs transcripts is required for effective Crb activity in epithelial polarity. J Cell Biol. 180:31-38.
4.  Liwei Wang, Zhouhua Li, Yu Cai*. 2008. The JAK/STAT pathway positively regulates DPP signaling in the Drosophila germline stem cell niche. J Cell Biol. 180: 721-728.
 
硕士招生方向:
    071009细胞生物学——干细胞生物学
    对专业背景无特殊限制,要求态度端正、认真负责、具有从事研究的热情。接收调剂生。同时欢迎立志科研的本/外校本科生来本实验室完成本科毕业论文。对于做出突出贡献和取得一定研究成果的学生,将获得参加国内外学术会议的机会,发表科研论文还可会获得额外的奖励。