李周华

作者:生命科学院 | 来源: | 发布日期:2014-03-12 | 阅读次数:

李周华/Zhouhua Li

 

博士,教授,博士生导师/Ph.D., Professor

 

Email: zhli@cnu.edu.cn

 

Tel:86-10-6890-1529(lab)

 

教育经历/Education:

2002/12—2009/04,新加坡国立大学淡马锡生命研究所,博士/Temasek

Life Sciences Laboratory (TLL), National University of Singapore (NUS), Ph.D.

1999/09—2002/07,中国农业大学生物学院,硕士/College of Biological Sciences, China Agricultural University (CAU), Master

1995/09—1999/07,山东农业大学园艺学院,学士/College of Horticulture Sciences, Shandong Agricultural University (SDAU), Bachelor

 

研究工作经历/Professional Experience:

2013/11—至今/present,首都师范大学生命科学学院,教授/School of Life Sciences, Capital Normal University (CNU), Professor

2010/09—2013/11,中国科学院动物研究所,副研究员/Institute of Zoology, Chinese Academy of Sciences (IOZ, CAS), Associate Professor

2010/05—2010/09,哈佛大学医学院,博士后/Harvard Medical School (HMS), Harvard University, Post-Doc Fellow

2009/01—2010/04,新加坡国立大学淡马锡生命研究所,研究员/TLL, NUS, Research Fellow

 

科研方向/Research Interests:

    干细胞分为胚胎干细胞和成体干细胞。成体干细胞的自我维持和分化在维持成体组织稳态和组织再生中发挥着至关重要的作用。干细胞自我维持和分化失调会导致衰老和癌症等一系列重大疾病的发生(图1),但调控干细胞自我维持和分化的分子机理尚不明了,因此阐明干细胞自我维持和分化的分子机制对干细胞生物学研究和疾病治疗等领域具有重要的科学意义和应用价值。

    本研究组以经典模式生物黑腹果蝇为研究对象,深入研究干细胞微环境及成体干细胞(胞囊干细胞、生殖干细胞和肠道干细胞)自我维持和分化及组织稳态的调控机制(图2)。

    研究方向:

    1、组织稳态调控与疾病;

    2、干细胞微环境的调控与维持;

    3、干细胞与体细胞间相互转化的机制。

  说明: http://smkxxy.cnu.edu.cn/images/content/2017-06/20170630170020915816.jpg

   Figure 1. The balance of self-renewal and differentiation of stem cell is critical for tissue homeostasis 

 

    The most prominent properties of stem cell are self-renewal and differentiation. The balance of stem cell self-renewal and differentiation must be tightly regulated in order to maintain tissue/organism homeostasis. De-regulation of this process will lead to a variety of diseases, like cancer and aging/degeneration (Fig. 1). However, the detailed mechanism controlling stem cell self-renewal and differentiation is not fully understood. Therefore, elucidating the molecular mechanism of stem cell regulation will provide new insights into our understanding of the mechanisms of stem cell proliferation and tissue homeostasis control, as well as the development of therapeutic applications to target human diseases.

 说明: http://smkxxy.cnu.edu.cn/images/content/2017-06/20170630170146200940.jpg

   

Figure 2. Adult stem cells studied in my lab

GSC: germline stem cell; ISC: intestinal stem cell.

 

    We are using Drosophila as a model system to study the mechanisms controlling stem cell self-renewal, proliferation, differentiation and tissue homeostasis. We mainly focus on adult stem cells, like cyst stem cells (CySCs), germline stem cells (GSCs), and intestinal stem cells (ISCs)(Fig.2).

    Research topics:

    1. Tissue homeostasis and dieases;

    2. Niche regulation;

    3. GSC-soma transition.

 

发表论文/Publications (*Corresponding author):

1.  Ran Xu, Jing Li, Hang Zhao, Ruiyan Kong, Min Wei, Lin Shi, Guang Bai, Zhouhua Li*. Self-restrained regulation of stem cell niche activities by niche components in the Drosophila testis. Developmental Biology, 2018, 439(1):42-51.

2.  Zhiqiang Bai, Zhouhua Li, Wei Xiao*. Drosophila Bendless catalyzes K63-linked polyubiquitination and is involved in the response to DNA damage. Mutation Research, 2018, 808:39-47.

3.  Meifang Ma, Hang Zhao, Hanfei Zhao, Richard Binari, Norbert Perrimon, Zhouhua Li*. Wildtype adult stem cells, unlike tumor cells, are resistant to cellular damages in Drosophila. Developmental Biology, 2016, 411(2):207-216.

4.  Wenyan Ren, Yan Zhang, Min  Li,  Longfei Wu,  Guolun Wang,  Gyeong-Hun Baeg, Jia You,  Zhouhua Li* , Xinhua  Lin*. Windpipe controls Drosophila intestinal homeostasis by regulating JAK/STAT pathway via promoting receptor endocytosis and lysosomal degradation. PLoS Genet., 2015, 11(4): e1005180.

5.  Yanfen Lu*, Zhouhua Li*. No intestinal stem cell regeneration after complete progenitor ablation in Drosophila adult midgut. J Genet. Genom., 2015, 42(2):83-86.

6.  Yanfen Lu*, Zhouhua Li*. Notch signaling downstream target E(spl)mbeta is dispensable for adult midgut homeostasis in Drosophila. Gene, 2015, 60(1):89-95.

7.  Zhouhua Li*, Sen Liu, Yu Cai*. EGFR/MAPK signaling regulates the proliferation of Drosophila renal and nephric stem cells. J Genet. Genom., 2015, 42(1):9-20.

8.  Zhouhua Li*, Sen Liu, Yu Cai*. Differential Notch activity is required for homeostasis of malpighian tubules in adult Drosophila. J Genet. Genom., 2014, 41(12):649-52.

9.  Xudong Huang,Lai Shi,Jun Cao,Fangfei He,Renling Li,Yan Zhang,Shuang Miao, Longjin Jin,Jia Qu,Zhouhua Li*, Xinhua Lin*. The sterile 20-like kinase Tao controls tissue homeostasis by regulating the Hippo pathway in Drosophila adult midgut. J Genet. Genom., 2014, 41(8):429-38.

10.  Yueqin Guo, Ying Feng, Zhouhua Li*, Xinhua Lin*. Drosophila heparan sulfate 3-O sulfotransferase B null mutant is viable and exhibits no defects in Notch signaling. J Genet. Genom., 2014, 41(7):369-78.

11.  Yueqin Guo, Zhouhua Li*, Xinhua Lin*. Hs3st-A and Hs3st-B regulate intestinal homeostasis in Drosophila adult midgut. Cell. Signal., 2014, 26(11): 2317-2325.

12.  Qinghai Zhang, Yan Zhang, Longfei Wu, Yongfei Yang, Xue Li, Lei Gao, Xiaomeng Hou, Yihui Wu, Guoli Hou, Zhouhua Li*, Xinhua Lin*. Brms1 acts as a positive regulator of Notch signaling in Drosophila wing. J Genet. Genom., 2014, 41(6):317-25.

13.  Jia You, Yan Zhang, Zhouhua Li, Zhefeng Lou, Longjin Jin, Xinhua Lin*. Drosophila Perlecan regulates intestinal stem cell activity via cell-matrix attachment. Stem Cell Reports. 2014, 2(6):761-9.

14.  Zhouhua Li*, Yueqin Guo, Lili Han, Yan Zhang, Lai Shi, Xudong Huang, Xinhua Lin*. Debra-mediated Ci degradation controls tissue homeostasis in Drosophila adult midgut. Stem Cell Reports, 2014, 2(2):135-144.

15.  Zhouhua Li, Yan Zhang, Lili Han, Lai Shi, Xinhua Lin*. Trachea-derived Dpp controls adult midgut homeostasis in Drosophila. Developmental Cell,, 2013, 24(2):133-143.

16.  Zhouhua Li, Liwei Wang, Hays Thomas, Yu Cai*. Dynein-mediated apical localization of crumbs transcripts is required for Crumbs activity in epithelial polarity. Journal of Cell Biololgy, 2008, 180(1):31-38.

17.  Liwei Wang, Zhouhua Li, Yu Cai*. The JAK/STAT pathway positively regulates DPP signaling in the Drosophila germline stem cell niche. Journal of Cell Biololgy, 2008, 180(4):721-728.

 

主持项目:

1、北京市自然科学基金面上项目,5162004,Stum调节肠道干细胞谱系分化的机理研究,2016/01-2017/12,18万元。

2、国家自然科学基金面上项目,31471384,抗增殖蛋白Prohibitin调节果蝇中肠稳态的机理研究,2015/01-2018/12,85 万元。

3、国家自然科学基金面上项目,31271582,气管来源的BMP信号维持果蝇中肠稳态的机理研究,2013/01-2016/12,82万元。

4、北京市自然科学基金-市教委重点项目,全新内源因子Yun调控肠道干细胞增殖和肠道组织稳态的分子机制,2019/01-2021/12,80万元。

 

招生方向:

     硕士招生方向:071009细胞生物学——干细胞生物学

     博士招生方向:071009细胞生物学——干细胞生物学

     对专业背景无特殊限制,要求考生态度端正、认真负责、具有从事科学研究的热情,接收调剂生,鼓励报考本实验室的考生来本实验室进行毕业设计和科研预热。对于做出突出贡献和取得一定研究成果的研究生,将获得参加国内外学术会议的机会,并可获得额外的奖励。